|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
|
22019778 |
2011 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P=0.0032; odds ratio (OR) 3.37, 95% confidence interval (CI) 1.45-7.87) was observed.
|
17075290 |
2006 |
|
Huntington Disease
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Our data provide evidence that caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop, and alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease.
|
16354923 |
2005 |
|
Peritonitis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Our study shows that upregulation of RIP2 is a useful marker to monitor dialysis-associated peritonitis and in predicting the clinical outcome of these infections.
|
17851464 |
2007 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection.
|
18426885 |
2008 |
|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
Ulcerative Colitis
|
0.320 |
Biomarker
|
disease |
CTD_human |
The present study was aimed at describing expression of innate immunity genes (NOD2, RIP2, α-defensins HD5 and HD6) in inflamed colon and in ileum of children with ulcerative colitis.
|
20452301 |
2010 |
|
Ulcerative Colitis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
The present study was aimed at describing expression of innate immunity genes (NOD2, RIP2, α-defensins HD5 and HD6) in inflamed colon and in ileum of children with ulcerative colitis.
|
20452301 |
2010 |
|
Ulcerative Colitis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Thus, F. nucleatum orchestrates a molecular network involving CARD3 and IL-17F to control the UC process.
|
31610014 |
2020 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Receptor-interacting serine/threonine protein kinase-2 (RIPK2) has been reported to be an important regulator of tumor proliferation, differentiation and wound repair.
|
22993319 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC, and in C57BL/6 mice, it reduced fibrosis and induced the influx of TILs.
|
29043413 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
A xenograft mouse model was used to assess tumor growth and chemosensitivity to docetaxel in vivo in MDA-MB-231 cells with and without RIP2 small hairpin RNA knockdown.
|
24642040 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
Genetic loss or pharmaceutical inhibition of RIP2 has been shown to be beneficial in multiple inflammatory disease models with the effects largely attributed to reducing proinflammatory signaling downstream of peptidoglycan recognition.
|
31113864 |
2019 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
|
25213858 |
2014 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
This article reviews the role that the NOD2:RIP2 complex plays in inflammatory disease, with an emphasis on the inhibition of this signaling pathway as a novel pharmaceutical target in inflammatory disease.
|
23794710 |
2013 |
|
Inflammatory disorder
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Further we show a second allele of RIPK2 linked to an inflammatory disease associated with arthritis also has enhanced activity stimulating the NF-κB pathway.
|
29659823 |
2018 |
|
Bacterial Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Collectively, these findings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autophagy and inflammatory signaling in response to bacterial infection.
|
24746552 |
2014 |
|
Bacterial Infections
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The results showed that NOD1 can identify LPS and activate the NF-κB signal pathway by recruiting RIPK2 and then promoting the expression of inflammatory cytokines to induce the resistance of organism against bacterial infection.
|
30013548 |
2018 |
|
Bacterial Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection.
|
31336107 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We have found association between RIPK2 (rs42490) and cancer risk (AA vs AT&TT, p=0042).
|
22504414 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Crohn Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
The present study is aimed at describing the downstream events triggered specifically by NOD2 induction in order to demonstrate that the protein, other than overexpressed, is also physiologically associated with RIP2 and Erbin in the bioptic intestinal inflamed specimens of children affected by CD.
|
19266573 |
2009 |